Biomedical applications of CFD

Computational hemodynamics

Posters and presentations

Gerk Rozema, Natasha Maurits, Arthur Veldman, Multi-scale modeling of the carotid artery. Poster at JM Burgers Day, January 2007.
Gerk Rozema, Natasha Maurits, Arthur Veldman, The Quasi-Simultaneous Approach for Partitioned Systems in Hemodynamics.. Poster at Dutch-Flemish Numerical Conference, Woudschoten, October 2008.
G. Rozema, A.E.P. Veldman, N.M. Maurits, Linking an artery to the circulation: introducing a quasi-simultaneous coupling approach for partitioned systems in hemodynamics. Presentation at EMBEC 2008, Antwerpen, November 24-28, 2008.
G. Rozema, N.M. Maurits, A.E.P. Veldman, Multi-scale modeling of the carotid artery. Presentation at UMCG, 2007.

Publications

Gerk Rozema, Arthur E.P. Veldman and Natasha M. Maurits, Quasi-simultaneous coupling methods for partitioned systems in computational hemodynamics. Applied Numerical Mathematics , 184 (2023) 461--481, DOI: https://doi.org/10.1016/j.apnum.2022.11.001
G. Rozema, N.M. Maurits, A.E.P. Veldman, Linking an artery to the circulation: introducing a quasi-simultaneous coupling approach for partitioned systems in hemodynamics. In: J. Vander Sloten, P. Verdonck, M. Nyssen, J. Haueisen (Eds.): ECIFMBE 2008, IFMBE Proceedings 22, pp. 1930-1934, 2008. www.springerlink.com (c) Springer-Verlag Berlin Heidelberg 2009
N.M. Maurits, G.E. Loots and A.E.P. Veldman, The influence of vessel wall elasticity and peripheral resistance on the flow wave form: a CFD model compared to in-vivo ultrasound meaurements. J. Biomech. 40(2) (2007) 427-436.
E. Loots, B. Hillen and A.E.P. Veldman, The role of hemodynamics in the development of the outflow tract of the heart. J. Eng. Math. 45 (2003) 91-104.
G.E. Loots, Fluid-structure interaction in hemodynamics. Promotores: prof.dr. A.E.P. Veldman, prof.dr.ir. H.W. Hoogstraten, prof.dr. B. Hillen. Rijksuniversiteit Groningen, May 9, 2003.
E. Loots, B. Hillen, H. Hoogstraten, A. Veldman, Fluid-structure interaction in the basilar artery. In: R. Herbin and D. Kroener (eds.) Finite Volumes for Complex Applications III , ISBN 1-9039-9634-1, Hermes Penton Science (2002) 607-614.
A. de Bruin, Numerical simulation of bloodflow through elastic vessels. Master Thesis, University of Groningen, June 2003.
N. Doggen, Plaque formation in the carotid bifurcation -- a numerical study. Master Thesis, University of Groningen, August 2002.
J. Ravensbergen, J.W. Ravensbergen, J.K.B. Krijger, B. Hillen and H.W. Hoogstraten, Localizing role of hemodynamics in atherosclerosis in several human vertebrobasilar junction geometries. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 708-716.
J. Ravensbergen, J.K.B. Krijger, A.L. Verdaasdonk, B. Hillen and H.W. Hoogstraten, The influence of the blunting of the apex on the flow in a vertebro-basilar junction model. ASME Journal of Biomechanical Engineering 119 (1997) 195-205.
J. Ravensbergen, J.K.B. Krijger, B. Hillen & H.W. Hoogstraten, The influence of the angle of confluence on the flow in a vertebro-basilar junction model. Journal of Biomechanics 29 (1996) 281-299.
J. Ravensbergen, J.K.B. Krijger, B. Hillen and H.W. Hoogstraten, Merging flows in an arterial confluence: the vertebro-basilar junction. Journal of Fluid Mechanics 304 (1995) 119-141.
J. Ravensbergen, J.K.B. Krijger, B. Hillen and H.W. Hoogstraten, The interaction between the morphology of and the flow in the basilar artery. European Journal of Morphology 33 (1995) 185.
J.K.B. Krijger, R.M. Heethaar, B. Hillen, H.W. Hoogstraten, J. Ravensbergen, Computation of steady 3-dimensional flow in a model of the basilar artery. J. Biomechanics 25 (1992) 1451-1465.
J.K.B. Krijger, Computational hemodynamcs of the basilar artery. Promotor: prof.dr.ir. H.W. Hoogstraten. Rijksuniversiteit Groningen, 1991.

Computational voice research

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Oscillating vocal chords
The movies show a simulation of elastic vocal chords interacting with an aerodynamic flow (modelled by Navier-Stokes). A constant pressure drop is applied over the pipe, after which the vocal chords start to oscillate -- computed with an extended version of Heat97 (M.P. de Vries - RuG Biomedical Engineering; M. Hamburg - UT).

Three-dimensional simulations haven been carried out by Monica Gorska and Manon Hegeman in their MSc theses. The following movie (25 Mb!) shows a simulation of oscillatory flow past a three-dimensional voice-producing element -- computed with ComFlo (M.M. Hegeman).

Publications

J. Lubbers, M.P. de Vries, A.E.P. Veldman and G.J. Verkerke, Influence of a downstream narrowing on the flow profile in a tube. J. Biomech. 39 (1) (2006) 70-77.
M.M. Hegeman, 3D Numerical modelling of a voice-producing element. Master Thesis, University of Groningen, June 2004.
M.P. de Vries, M.C. Hamburg, H.K. Schutte, G.J. Verkerke and A.E.P. Veldman, Numerical simulation of a voice-producing element based on Navier-Stokes equations and the finite-element method. J. Acoust. Soc. America 113 (2003) 2077-2083.
M. Gorska, Numerical modelling of a voice-producing element. Master Thesis, University of Groningen, December 2002.
M.P. de Vries, H.K. Schutte, A.E.P. Veldman and G.J. Verkerke, Glottal flow through a two-mass model: comparison of Navier-Stokes solutions with simplified models. J. Acoust. Soc. America 111 (2002) 1847-1853.
M.P. de Vries, A new voice for the voiceless. Design and in-vitro testing of a voice-producing element. Promotores: prof.dr. H.K. Schutte, prof.dr. A.E.P. Veldman; referenten: dr.ir. G.J. Verkerke, dr.ir. A. Hirschberg. Rijksuniversiteit Groningen, July 5, 2000.
M.P. de Vries, A. van der Plaats, F.J.M. van der Eerden, A.E.P. Veldman, H.K. Schutte en G.J. Verkerke, Ontwikkeling van een testopstelling voor de stemvormende prothese. Journaal Nederlands Akoestisch Genootschap 146 (1999) 21-26.

Computational embrionics

Together with the Dept. of Radiology of the University of Manitoba, research is carried out on embryo development under micro-gravity.

Publications

C. Nouri, R. Luppes, A.E.P. Veldman, J.A. Tuszynski and R. Gordon, Rayleigh instability of the inverted one-cell amphibian embryo. Physical Biology 5(1) (2008) article 015006.

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Department of Mathematics
University of Groningen